Paradoxical Obesity in Atrial Fibrillation: Myth or Reality?
Keywords:
paradoxical obesity; atrial fibrillation; mortality.Abstract
Introduction: Obesity is an independent risk factor for the development of atrial fibrillation; however, it has been observed in patients diagnosed with this arrhythmia that it acts as a protective factor against mortality.
Objective: To update knowledge on the phenomenon of the obesity paradox in atrial fibrillation.
Method: A literature review of 20 articles was conducted using PubMed, Scopus, SciELO, Lilacs, and Cochrane Library databases via Google Scholar search engine. The search terms used were paradoxical obesity, atrial fibrillation, and mortality. Original articles, observational studies, clinical trials, and meta-analyses published in Spanish or English from 2016 to 2024 were consulted.
Results: Obesity is a predictor of mortality in patients with atrial fibrillation; However, it has been shown to improve the prognosis for these patients by decreasing the rates of cerebrovascular events and systemic thromboembolisms, thus reducing mortality.
Conclusions: The obesity paradox is a reality in patients with atrial fibrillation.
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References
1. Li YG, Xie PX, Alsheikh Ali AA, AlMahmeed W, Sulaiman K, Assad N, et al. The “obesity paradox” in patients with atrial fibrillation: Insights from the Gulf SAFE registry. Front. Cardiovasc. Med. 2022;9:1032633. DOI: https://doi.org/10.3389/fcvm.2022.1032633
2. González Cambeiro MC, Rodríguez Mañero M, Abu Assi E, Raposeiras Roubin S, González Juanatey JR. Review of obesity and atrial fibrillation: Exploring the paradox. Journal of Atrial Fibrillation. 2015;8(2):1259. DOI: https://doi.org/10.4022/jafib.1259
3. Ibdah R, Abdalmajeed A, Atoum K, Alenazi L, Al Omary A, Hammoudeh A, et al. Association of body mass index with outcomes in patients with atrial fibrillation: Analysis from the JoFib registry. Vascular Health and Risk Management. 2024:20. DOI: https://doi.org/10.2147/VHRM.5444894
4. Novaes Lima AI, Costa do Rego Barros M, Almeida de Barros Guimarães A, Celestino Sobral D. Obesity paradox in atrial fibrillation and its relation with the new oral anticoagulants. Current Cardiology Reviews. 2022;18(5). DOI https://doi.org/10.2174/1573403X18666220324111343
5. Prashanthan S, Lau DH. Mortality paradox in obesity and atrial fibrillation. True clinical phenomenon or red herring in atrial fibrillation care? JACC: Clinical Electrophysiology. 2016;2(5). DOI: https://doi.org/10.1016/j.jacep.2016.02.001
6. Sandhu RK, Ezekowitz J, Andersson U, Alexander JH, Granger CB, Halvorsen S, et al. The “obesity paradox” in atrial fibrillation: Observations from the ARISTOTLE (Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation) trial. Eur Heart J. 2016;37(38):2869-78. DOI: http://dx.doi.org/10.1093/eurheartj/ehw124
7. Ramírez Penuela JA, Buitrago AF. Predictores de mortalidad en pacientes hospitalizados con fibrilación auricular en un hospital universitario. Rev Colomb Cardio. 2019;26(6):322-7. DOI: https://doi.org/10.1016/j.rccar.2018.10.012
8. Sociedad Española de Cardiología. Guía ESC 2024 sobre el manejo de la fibrilación auricular. 2024 [acceso 02/02/2025]. Disponible en: https://secardiologia.es/publicaciones/catalogo/guias/15404-guia-esc-2024-sobre-sobre-el-manejo-de-la-fibrilacion-auricular
9. Proietti M, Guiducci E, Cheli P, Lip G. Is there an obesity paradox four outcomes in atrial fibrillation? A systematic review and meta - analysis of non - vitamin K antagonist oral anticoagulant trials. Stroke. 2017;48:857-66. DOI: https://doi.org/10.1161/strokeaha.116.016984.
10. Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int 1999;55:1560-7. DOI: https://doi.org/10.1046/j.1523-1755.1999.00389.x
11. In Chang Hwang. The obesity paradox: An epiphenomenon vs. a clue for the hidden pathophysiology of adiposity. Korean Circ J. 2023;53(12):855-7. DOI: https://doi.org/10.4070/kcj.2023.0278
12. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Woo MA, Tillisch. The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol. 2001;38(3):789-95. DOI: https://doi.org/10.1016/s0735-1097(01)01448-6.
13. Grymonprez M, Capiau A, De Backer TL, Steurbaut S, Boussery K, Lahousse L. The impact of underweight and obesity on outcomes in anticoagulated patients with atrial fibrillation: A systematic review and meta-analysis on the obesity paradox. Clin Cardiol. 2021;44(5):599-608. DOI: https://doi.org/10.1002/clc.23593
14. Lee SR, Choi EK, Jung JH, Park SH, Han KD, Oh S, et al. Body mass index and clinical outcomes in Asian patients with atrial fibrillation receiving oral anticoagulation. Stroke. 2021;52(2):521-30. DOI: https://doi.org/10.1161/STROKEAHA.120.030356
15. Zhou Y, Ma J, Zhu W. Efficacy and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation across BMI categories: A systematic review and meta- analysis. Am J Cardiovasc Drugs. 2020;20(1):51-60. DOI: https://doi.org/10.1007/s40256-019-00362-4
16. Lucijanic M, Jurin I, Jurin H, Lucijanic T, Starcevic B, Skelin M, et al. Patients with higher body mass index treated with direct/novel oral anticoagulants (DOAC/NOAC) for atrial fibrillation experience worse clinical outcomes. Int J Cardiol. 2020;301:90-5. DOI: https://doi.org/10.1016/j.ijcard.2019.10.035
17. Wang H, Wang HJ, Chen YD, Tao T, Guo YT, Zhao XN, et al. Prognostic factors of clinical endpoints in elderly patients with atrial fibrillation during a 2 year follow up in China: An observational cohort study. Medicine (Baltimore). 2017;96(33):e7679. DOI: https://doi.org/10.1097/MD.0000000000007679
18. Boriani G, Ruff CT, Kuder JF, Shi M, Lanz HJ, Rutman H, et al. Relationship between body mass index and outcomes in patients with atrial fibrillation treated with edoxaban or warfarin in the ENGAGE AF TIMI 48 trial. Eur Heart J. 2019;40(19):1541-50. DOI: https://doi.org/10.1093/eurheartj/ehy861
19. Ardestani A, Hoffman HJ, Cooper HA. Obesity and outcomes among patients with established atrial fibrillation. Am J Cardiol. 2010;106:369-73. DOI: https://doi.org/10.1016/j.amjcard.2010.03.036
20. Balla SR, Cyr DD, Lokhnygina Y, Becker RC, Berkowitz SD, Breithardt G, et al. Relation of risk of stroke in patients with atrial fibrillation to body mass index (from patients treated with rivaroxaban and warfarin in the rivaroxaban once daily oral direct factor X a inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation trial). Am J Cardiol. 2017;119(12):1989-96. DOI: https://doi.org/10.1016/j.amjcard.2017.03.028
21. Donini LM, Pinto A, Giusti AM, Lenzi A, Poggiogalle E. Obesity or BMI Paradox? Beneath the Tip of the Iceberg. Front. Nutr. 2020;7:53. DOI: https://doi.org/10.3389/fnut.2020.00053
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