Plummer-Vinson Syndrome
Keywords:
Síndrome Plummer-Vinson, síndrome de Paterson-Brown-Kelly, anemia ferropénica crónica, membrana esofágica, cáncer esofágico de células escamosas.Abstract
Introduction: Plummer-Vinson syndrome is a rare entity, still under study, which is characterized by the presence of dysphagia, esophageal web formation, and iron deficiency anemia. It is more common in the female population, especially in middle age, with higher risk of developing a squamous cell neoplasia of the pharynx in the proximal esophagus. There are various hypotheses on its pathogenesis that are still under study, but iron deficiency is the most invoked, as it is responsible for the anatomical and functional alterations that occur at the esophageal level. The diagnosis is clinical, laboratory, and imaging; upper digestive endoscopy is an essential tool that allows the therapeutic approach, other treatment modalities consist of iron replacement, as well as endoscopic techniques that vary according to the experience and availability of each center.
Objective: To report three cases of Plummer-Vinson syndrome.
Case report: We present three clinical cases of this syndrome, all with certain degree of dysphagia conditioned by the presence of proximal esophageal webs and iron deficiency anemia.
Conclusions: The three patients diagnosed with Plummer-Vinson syndrome evolved satisfactorily with oral or parenteral iron treatment, as appropriate, and endoscopic treatment was performed for dysphagia with uncomplicated rupture of the diagnosed esophageal webs.
Keywords: Plummer-Vinson syndrome; Paterson-Brown-Kelly syndrome; chronic iron deficiency anemia; esophageal web; esophageal squamous cell cancer.
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Copyright (c) 2025 Mario Jesús García Ayala, Yanina Celeny Reyes Cruz, Roberto Pérez Menéndez
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