Prognostic factors for autologous transplantation in patients with Hodgkin Lymphoma

Authors

  • Calixto Hernández Cruz Hospital Clínico Quirúrgico "Hermanos Ameijeiras"
  • José Carnot Uria Hospital C.Q.‟Hermanos Ameijeiras
  • Jorge Jorge Muñío Perurena Hospital C.Q.‟Hermanos Ameijeiras
  • Aliette García García Hospital C.Q.‟Hermanos Ameijeiras
  • Oliday Ríos Jiménez Hospital C.Q.‟Hermanos Ameijeiras
  • Yusaima Rodríguez Fraga Hospital C.Q.‟Hermanos Ameijeiras

Keywords:

Trasplante autólogo de progenitores hematopoyéticos, linfoma de Hodgkin, factores pronósticos

Abstract

Introduction: Autologous hematopoietic stem cell transplantation is a therapy used in certain situations to patients with Hodgkin's Lymphoma.

Objective: To evaluate the influence of selected prognostic factors on the results of autologous hematopoietic stem cell transplantation in patients with Hodgkin's Lymphoma.

Methods: A retrospective study of 57 patients with a diagnosis of Hodgkin Lymphoma transplanted at Hermanos Ameijeiras Clinical Surgical Hospital from 1991 to 2018 was carried out. The influence of several unfavorable factors was evaluated according to univariate and multivariate disease-free survival at five years.

Results: A lower disease-free survival was found for all groups with unfavorable categories. Univariate analysis indicated that receiving three or more previous lines of treatment increased the probability of relapse on average 3.48 times. In the multiple evaluation, the probability of relapse was significantly increased by the existence of active disease at the time of transplantation (p = 0.023) and by not receiving radiotherapy in the conditioning treatment (p = 0.010).

Conclusions: The importance of knowing the unfavorable factors was established. It was of noteworthy importance to avoid active disease at transplantation and to carry out a correct evaluation of risks and benefits regarding the possible inclusion of radiotherapy in the conditioning treatment.

 

Keywords: autologous hematopoietic stem cell transplantation; Hodgkin's lymphoma; prognostic factors.

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Published

2021-03-09

How to Cite

1.
Hernández Cruz C, Carnot Uria J, Jorge Muñío Perurena J, García García A, Ríos Jiménez O, Rodríguez Fraga Y. Prognostic factors for autologous transplantation in patients with Hodgkin Lymphoma. Rev Cubana Med [Internet]. 2021 Mar. 9 [cited 2025 Mar. 12];60(3). Available from: https://revmedicina.sld.cu/index.php/med/article/view/2515

Issue

Vol. 60 No. 3 (2021): julio-septiembre

Section

Original articles

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