Dipeptidyl peptidase 4 and its function against COVID-19

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Keywords:

Dipeptidil peptidasa 4, COVID-19, inhibidores de dipeptidil peptidasa 4

Abstract

Given the appearance of a "new virus" in the of Wuhan city, China, called SARS-CoV-2, which causes the well-known severe acute respiratory syndrome (COVID-19), many scientists are trying to find a solution against the virus that has caused a pandemic. In this search, a transmembrane glycoprotein called dipeptidyl peptidase 4 or DPP-4 was found present on the surface of different types of cells and a target in MERS-Co-V infection, which opens hope by suspecting that DPP- 4 can be a target in different coronaviruses by serving as a therapeutic strategy. Added to this, there are results that find elevated DPP-4 in patients with severe complications from COVID-19, which may be a possible marker of severity. However, there is still little emphasis on the identification and association of this glycoprotein with COVID-19. To this effect, a bibliographic review was carried out on the most significant aspects of Dipeptidyl Peptidase 4 and its function against COVID-19.

Keywords: dipeptidyl peptidase 4; COVID-19; dipeptidyl peptidase 4 inhibitors.

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Author Biographies

Marisol Susan Poma Castillo, Universidad Privada Antenor Orrego

Bachiller de Medicina Humana

Victor Hugo Bardales Zuta, Universidad Privada Antenor Orrego

Medico Internista

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Published

2022-03-06

How to Cite

1.
Poma Castillo MS, Bardales Zuta VH. Dipeptidyl peptidase 4 and its function against COVID-19. Rev Cubana Med [Internet]. 2022 Mar. 6 [cited 2025 Jun. 20];61(1). Available from: https://revmedicina.sld.cu/index.php/med/article/view/2413

Issue

Vol. 61 No. 1 (2022): enero-marzo

Section

Review articles

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