New molecular and pathophysiological aspects of sickle cell anemia

Authors

  • Gilberto Soler Noda Instituto de Hematología e Inmunología

Abstract

Introduction: Hemoglobin S disease is a hereditary chronic hemolytic anemia whose clinical manifestations come from the tendency of this hemoglobin to polymerize and deform erythrocytes, giving the typical crescent, banana, sickle cell or "sickle cell" shape; hence the name sickle cell anemia or sicklemia.

Objective: To describe the new molecular and pathophysiological aspects and the diagnosis of sickle cell anemia.

Methods: A literature review was carried out, in English and Spanish, through PubMed website and Google academic search engine for articles published in the last 10 years. An analysis and summary of the revised bibliography was made.

Conclusions: Understanding the complexity and multiplicity of events that lead to serious complications in sickle cell anemia and our inability to predict the clinical course in each particular case would help preventing these events.

Keywords: hemoglobinopathies; HbS; Sickle-cell anaemia; sicklemia; abnormal hemoglobins.

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Author Biography

Gilberto Soler Noda, Instituto de Hematología e Inmunología

Licenciado en Tecnología de la Salud, Especialidad Medicina Transfusional. Máster en Bioquímica e Inmunología. Profesor e Investigador Auxiliar. Facultad de Tecnología de la Salud. Universidad de Ciencias Médicas de La Habana. Instituto de Hematología e Inmunología. La Habana. Cuba.

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Published

2020-09-18

How to Cite

1.
Soler Noda G. New molecular and pathophysiological aspects of sickle cell anemia. Rev Cubana Med [Internet]. 2020 Sep. 18 [cited 2025 Jul. 7];60(1). Available from: https://revmedicina.sld.cu/index.php/med/article/view/505

Issue

Vol. 60 No. 1 (2021): enero-marzo

Section

Review articles

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