Association of Neutrophils/Lymphocytes and Platelets/Lymphocytes with Activity in Patients with Rheumatoid Arthritis
Keywords:
Artritis Reumatoide, relación neutrófilo/linfocito y relación plaquetas/linfocitos.Abstract
Introduction: Neutrophils, lymphocytes, and platelets play an important role in the inflammatory process of rheumatoid arthritis.
Objective: To identify the association among the neutrophil/lymphocyte and platelet/lymphocyte ratios and disease activity.
Methods: A descriptive, cross-sectional study was conducted in patients with rheumatoid arthritis in the Rheumatology Department of Hermanos Ameijeiras Clinical-Surgical Teaching Hospital from 2021 to 2023. Demographic and clinical variables, as well as clinical inflammatory activity, were considered. Hematological neutrophil, platelet, and lymphocyte counts were determined using the erythrocyte sedimentation rate. The neutrophil/lymphocyte and platelet/lymphocyte ratios were calculated. In addition, we studied whether these were related to disease activity and their association with clinical characteristics.
Results: A total of 703 patients were included. Neutrophil and platelet counts differed significantly between active and inactive patients (p < 0.021 and p < 0.023). The neutrophil/lymphocyte and platelet/lymphocyte ratios differed significantly between active and inactive patients; the neutrophil/lymphocyte ratio was 2.8 (± 1.5) vs. 2.6 (± 1.8) and the platelet/lymphocyte ratio was 180.7 (± 81.2) vs. 171.3 (± 80.5) (p = 0.002). The neutrophil/lymphocyte and platelet/lymphocyte ratios were associated with the presence of arthritis and morning stiffness; the neutrophil/lymphocyte ratio was 81 (40.9%) (p < 0.001) vs. 86 (39.4%) (p < 0.001); and the platelet/lymphocyte ratio was 22 (11.1%) (p < 0.003) vs. 24 (11%) (p < 0.002).
Conclusions: The hematological markers analyzed were associated with the inflammatory activity of the disease.
Keywords: rheumatoid arthritis; neutrophil/lymphocyte ratio; platelet/lymphocyte ratio.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Araceli Chico Capote, Yarilemnys Alonso León, Miguen Hernán Estévez del Toro, Roberto Iván Vaca Riofrío, Rolando Dayan Puente Carmona, Ana Lidia Moreira León
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The Cuban Journal of Medicine protects the author's patrimonial rights. However, it is licensed under a Creative Commons Licensehttps://creativecommons.org/licenses/by-nc/4.0/deed.es_ES which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided that the primary source of publication is duly cited. The author always retains his moral rights.
You are free to:
- Share - copy and redistribute the material in any medium or format.
- Adapt - remix, transform and build upon the material
- The license cannot revoke these freedoms as long as you follow the terms of the license.
Under the following terms:
- Attribution - You must give proper credit, provide a link to the license, and indicate if changes have been made. You may do so in any reasonable manner, but not in such a way as to suggest that you or your use is supported by the licensor.
- Non-Commercial Purpose- You may not make use of the material for commercial purposes.
- No Additional Restrictions - You may not apply legal terms or technological measures that legally restrict others from making any use permitted by the license.
