Rheumatological Manifestations in Crohn's Disease
Keywords:
axial arthritis; peripheral arthritis; Crohn's disease; spondyloarthropathies; sacroiliitis.Abstract
Inflammatory bowel disease (IBD) is a chronic, idiopathic disease that affects the gastrointestinal tract. Its two main forms are Crohn's disease and ulcerative colitis. Among its complications are rheumatological conditions, which are divided into four categories: peripheral arthritis, spondylitis (with or without sacroiliitis), isolated sacroiliitis, and a fourth, less common category. Peripheral arthritis is the most frequent (5-30%) of them. The onset of arthritis is usually simultaneous with or after the gastrointestinal manifestations. It is worth noting that less than 10% of patients with spondyloarthropathies will develop definitive IBD.
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References
1. Guan Q. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. J Immunol Res. 2019;2019:7247238. DOI: http://dx.doi.org/10.1155/2019/7247238
2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life. 2019;12(2):113-22. DOI: http://dx.doi.org/10.25122/jml-2018-0075
3. Wawrzyniak M, Scharl M. Genetics and epigenetics of inflammatory bowel disease. Swiss Med Wkly. 2018;148:w14671. DOI: http://dx.doi.org/10.4414/smw.2018.14671
4. Juillerat P, Manz M, Sauter B, Zeitz J, Vavricka SR; Swiss IB. An official working group of the Swiss Society of Gastroenterology. Therapies in Inflammatory Bowel Disease Patients with Extraintestinal Manifestations. Digestion. 2020;101(1):83-97. DOI: http://dx.doi.org/10.1159/000502816
5. Luzoro A, Sabat P, Guzmán L, Frias F. Manifestaciones extraintestinales de enfermedad inflamatoria intestinal. Rev Médica Clín Las Condes. 2019;30(4):305-14.DOI: http://dx.doi.org/10.1016/j.rmclc.2019.06.001
6. Adam H, Alqassas M, Saadah OI, Mosli M. Manifestaciones extraintestinales de la enfermedad inflamatoria intestinal en pacientes del Medio Oriente. J Epidemiol Glob Health. 2020;10(4):298-303. DOI: http://dx.doi.org/10.2991/jegh.k.200330.001
7. Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;68(6):777-83. DOI: http://dx.doi.org/10.1136/ard.2009.108233
8. Cerrillo E, Sáez E, Bastida G, Nos P. Manifestaciones extraintestinales en la enfermedad inflamatoria intestinal. Medicine. 2020;13(11):618-30 DOI: https://doi.org/10.1016/j.med.2020.06.013
9. Felice C, Pugliese D, Papparella LG, Pizzolante F, Onori E, Gasbarrini A, et al. Clinical management of rheumatologic conditions co-occurring with inflammatory bowel diseases. Expert Rev Clin Immunol. 2018;14(9):751-9. DOI: http://dx.doi.org/10.1080/1744666X.2018.1513329
10. Juliao-Baños F, Arrubla M, Osorio L, Camargo J, Londoño J, Cáceres C, et al. Characterization and prevalence of extraintestinal manifestations in a cohort of patients with inflammatory intestinal disease in Medellin, Colombia. Gastroenterol Hepatol. 2021;44(6):398-404. DOI: http://dx.doi.org/10.1016/j.gastrohep.2020.07.012
11. Rogler G, Singh A, Kavanaugh A, Rubin D. Manifestaciones extraintestinales de la enfermedad inflamatoria intestinal: conceptos, tratamiento e implicaciones actuales para el manejo de la enfermedad. Reseñas en gastroenterología básica y clínica y hepatología. 2021 [acceso 14/03/2024];161(4):30-32. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564770/
12. Chen J, Liu C. Sulfasalazine for ankylosing spondylitis. Cochrane Database Syst Rev. 2005;18(2):CD004800. DOI: http://dx.doi.org/10.1002/14651858.CD004800.pub2
13. Annese V. A Review of Extraintestinal Manifestations and Complications of Inflammatory Bowel Disease. Saudi J Med Med Sci. 2019;7(2):66-73. DOI: http://dx.doi.org/10.4103/sjmms.sjmms_81_18
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