Impact of Serum Creatinine Correction on Estimation of Renal Function
Keywords:
creatinina, tasa de filtración glomerular, Cuba, Enfermedad Renal CrónicaAbstract
Introduction: Renal function is usually estimated from glomerular filtration rates calculated with creatinine.
Objectives: To evaluate the impact of arithmetic correction of serum creatinine concentrations against a reference method in the estimation of renal function.
Methods: An observational, descriptive, cross-sectional study was conducted. The universe consisted of all subjects included in PLAZERC study at Policlínico Plaza from March to April 2023. For statistical analysis, the following were used: frequency distributions, mean, standard deviation, and Bland-Altman diagrams to determine the agreement between the estimated glomerular filtration rates, calculated from creatinine obtained by three measurement methods, and after their correction to a reference method.
Results: One thousand and forty-two subjects were studied, 56.9% were 60 years old and older, the average glomerular filtration rate was 88.30 ml/min/1.73m2SC, 5.8% had hematuria and 9.3% had albuminuria. The differences in prevalence of chronic kidney disease were less than 1% with the CKD-EPI equations of 2009 and 2021. With the manual method, an overall prevalence of 11.13% was overestimated and with the automated method, 3.7%. With the correction to the reference method, the differences in renal function were less than 2%.
Conclusions: The classification of chronic kidney disease is modified based on the method used to measure creatinine, with overdiagnosis if correction to a reference method is not performed.
Keywords: creatinine; glomerular filtration rate; Cuba; chronic kidney disease
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Copyright (c) 2025 Raymed ANTONIO Bacallao Méndez, Yanetsy Córdova Rodríguez, Eduardo Antonio George Estévez, Javier Maure Barcia, Yamile García Villar, Carlos Antonio Rodríguez García
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