Association between Albuminemia and the Neutrophil/Lymphocyte Ratio in Rheumatoid Arthritis Patients
Keywords:
albumin, neutrophil/lymphocyte ratio, rheumatoid arthritis.Abstract
Introduction: Various evidences have shown that systemic inflammation and malnutrition could be associated with the disease activity of patients with rheumatoid arthritis and it could contribute to the pathogenesis and progression of the disease.
Objective: To determine the association between albuminemia and the ratio of neutrophils and lymphocytes with disease activity in patients with rheumatoid arthritis.
Methods: An analytical, cross-sectional cohort study was carried out on 761 patients treated in the protocolized consultation of Hermanos Ameijeiras Clinical Surgical Hospital from September 2021 to March 2023.
Results: The study population was characterized by predominance of the female sex (88%), average age of 54.5 years, white skin (57.2%), overweight and obese (72.2%), the average evolution time was 10.7 years and moderate disease activity (50.5%). 72% had elevated neutrophil to lymphocyte ratio. Albumin showed inverse and significant correlation with erythrocyte sedimentation rate and C-reactive protein. Both elevated neutrophil-lymphocyte ratio and albumin-derived neutrophil-lymphocyte ratio were associated with disease activity.
Conclusions: Albumin and the ratio of neutrophils and lymphocytes are parameters that are related in patients with rheumatoid arthritis and the activity of the disease, especially when both are combined.
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