Autologous Hematopoietic Stem Cell Transplantation in Patients with Multiple Myeloma
Keywords:
multiple myeloma, treatment, survival.Abstract
Introduction: Autologous hematopoietic stem cell transplantation is part of the advances in the treatment of patients diagnosed with multiple myeloma in recent years.
Objective: To evaluate the results of autologous hematopoietic stem cell transplantation in patients with multiple myeloma.
Methods: A descriptive, retrospective and cohort study was carried out, forming a sample of 15 patients treated in the Hematology Service at Hermanos Ameijeiras Clinical Surgical Hospital from November 2009 to November 2019.
Results: The average age was 54.67 years; 53.3% were male and all debuted in Durie-Salmon stage III. As conditioning for the transplant, 67.7% received high doses of melphalan at doses of 200 mg/m2. Cytopenias and gastrointestinal toxicity were the most common complications (93.3%). The recovery of neutrophil and platelet numbers occurred on average after 11 days, only two patients died (13.3%) and 13 (86.7%) are in complete remission with a probability of overall survival at 5 years, 77.8%.
Conclusions: Transplantation of autologous hematopoietic stem cells with the use of high doses of melphalan as conditioning in patients with multiple myeloma is a feasible procedure with a relatively low mortality and demonstrates that its inclusion in the treatment of patients considerably improves their survival expectations.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
The Cuban Journal of Medicine protects the author's patrimonial rights. However, it is licensed under a Creative Commons Licensehttps://creativecommons.org/licenses/by-nc/4.0/deed.es_ES which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided that the primary source of publication is duly cited. The author always retains his moral rights.
You are free to:
- Share - copy and redistribute the material in any medium or format.
- Adapt - remix, transform and build upon the material
- The license cannot revoke these freedoms as long as you follow the terms of the license.
Under the following terms:
- Attribution - You must give proper credit, provide a link to the license, and indicate if changes have been made. You may do so in any reasonable manner, but not in such a way as to suggest that you or your use is supported by the licensor.
- Non-Commercial Purpose- You may not make use of the material for commercial purposes.
- No Additional Restrictions - You may not apply legal terms or technological measures that legally restrict others from making any use permitted by the license.
