Mortality Predictors in Patients with Severe Dengue
Keywords:
dengue, dengue grave, factores de mortalidad, factores de riesgo.Abstract
Introduction: Dengue has a wide clinical spectrum, ranging from asymptomatic infection to severe forms with a high risk of mortality.
Objective: To determine the clinical, biochemical and imaging predictors of mortality in patients with severe dengue.
Methods: A systematic review of the literature was carried out in SciELO, Science Direct, PubMed and Google Scholar databases, and a review of the repositories of scientific societies and the references of the included documents was also carried out. The study protocol was built following the PRISMA-ScR guidelines.
Results: Age 45 years and older is associated with mortality from severe dengue (OR = 0.141, 95% CI: 0.034-0.585, p = 0.007). Patients under 10 years of age are also at risk of mortality from severe dengue. On the other hand, arterial hypertension is a significant predictor of mortality from severe dengue (16.7% of the total), as well as diabetes (OR = 13.42 CI 1.51-118.62). Laboratory predictors such as thrombocytopenia and leukocytosis were associated with high mortality rates from severe dengue. Among the imaging factors, pericardial effusion is a significant predictor of mortality as well as pleural effusion (p <0.001).
Conclusions: The clinical, biochemical and imaging predictors of mortality in patients with severe dengue were determined. Patients > 45 years old, presence of comorbidities (diabetes, arterial hypertension), drug administration, bleeding and shock; laboratory: leukocytosis, thrombocytosis, decreased albumin, hematocrit and increased creatinine; imaging: pleural and pericardial effusion.
Keywords: dengue; severe dengue; mortality factors; risk factors.
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Copyright (c) 2025 Katherine Jhessenia Angeles López, Guillermo Alber Arana Morales, Melina Lucero de Maria Villegas Vidal, Karen Elizabeth Vásquez Santos, Hermes Marcelo Fernández Huaccha
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