Association of Epidemiological, Clinical, Radiological, Microbiological and Xpert Criteria with the Diagnosis of Active Pulmonary Tuberculosis

Authors

Keywords:

association, diagnosis, symptoms and signs, sensitivity and specificity, pulmonary tuberculosis.

Abstract

Introduction: Tuberculosis is a re-emerging and infectious disease caused by Mycobacterium tuberculosis.

Objective: To determine the level of individual association of the epidemiological, clinical, radiological, microbiological criteria and the Xpert MTB/RIF with the diagnosis of active pulmonary tuberculosis.

Methods: A case-control study was carried out from September 2020 to March 2022 in patients with suspected active pulmonary tuberculosis at the time of admission or during their stay in the Internal Medicine Service at Vladimir Ilich Lenin University General Hospital. The characteristics of the groups were described. The sensitivity and specificity of smear microscopy, culture, and Xpert MTB/RIF testing were determined.

The level of association of the criteria with the diagnosis of active pulmonary tuberculosis was calculated using Cramer's V.

Results: 38.9% of the cases were between 51-60 years old, 61.1% were male and had white skin. The radiological criteria were present in 94.4% of the cases and the Xpert MTB/RIF test was positive in 100% of the patients. Smear microscopy and culture shared 88.89% of sensitivity (95% CI: 71.59%-100%) and 100% of specificity (95% CI: 98.75%-100%). The level of association of the X-pert MTB/RIF test with the diagnosis of active pulmonary tuberculosis was 0.93 (p < 0.01).

Conclusions: Radiological diagnostic criteria, smear microscopy, culture and the Xpert MTB/RIF test presented a strong association with the diagnosis of active pulmonary tuberculosis.

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Author Biographies

Ivonne María Nodarse-Palacios, Hospital General Universitario "Vladimir Ilich Lenin"

Especialista en Medicina Interna

Yoander Nápoles-Zaldivar, Hospital General Universitario Vladimir Ilich Lenin

Especialista de 1er Grado en Medicina Interna. Profesor Instructor. Aspirante a Investigador. Miembro de la SOCUMI y de la Sociedad Cubana de Cardiología.

Abelardo Rafael Rubio-Rodríguez, Hospital General Universitario Vladimir Ilich Lenin

Especialista de 2do Grado en Medicina Interna. Máster en Enfermedades Infecciosas.

Lidia Elena Cuba-Sainz, Hospital General Universitario Vladimir Ilich Lenin

Especialista en 1er Grado en Neumotisiología

Published

2024-08-02

How to Cite

1.
Nodarse-Palacios IM, Nápoles-Zaldivar Y, Rubio-Rodríguez AR, Cuba-Sainz LE. Association of Epidemiological, Clinical, Radiological, Microbiological and Xpert Criteria with the Diagnosis of Active Pulmonary Tuberculosis. Rev Cubana Med [Internet]. 2024 Aug. 2 [cited 2025 Jul. 27];63. Available from: https://revmedicina.sld.cu/index.php/med/article/view/3418

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Original articles