Hyperhomocysteinemia as a Risk Factor in Obstructive Vascular Diseases
Keywords:
occlusive vascular disease, ischemic heart disease, homocysteine, hyperhomocysteinemia.Abstract
Introduction: Homocysteine is considered an atherogenic factor in various diseases such as cardiovascular and cerebrovascular diseases. Hyperhomocysteinemia is a condition of variable cause as a risk factor in obstructive vascular diseases.
Objective: To study the increase in homocysteine levels in the blood as a risk indicator for obstructive vascular diseases.
Methods: A prospective-analytical study was carried out on the variations in serum levels of complete blood count in patients, with a diagnosis of obstructive vascular diseases, who were admitted to Hermanos Ameijeiras Hospital in 2022. The sample consisted of 100 patients. The reliability was 95%, the statistical power was 80% and 25% of the exposure to the factor to be evaluated, an estimated odds ratio of 5.00 and a ratio of 1:1, (50 cases and 50 controls).
Results: Patients over 50 years of age predominated in the study, but no significant difference was detected with respect to sex. Ischemic heart disease was the OVD with the highest incidence. Hyperhomocysteinemia was an excellent marker of VOD in the patients studied, unlike controls.
Conclusions: The study demonstrated a statistically significant positive association between hyperhomocysteinemia and obstructive vascular diseases, confirming the value of Hc as a risk predictor for this diseaseDownloads
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